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OPC-14117 has shown promising results in animal models of neurodegenerative disorders (Klivenyi et al., 2003) and Parkinsons disease (Spinnewyn et al., 2011) and amyotrophic lateral sclerosis ( + channel blockage and COX-inhibitory activities
The interaction and mutual promotion of these three factors are thought to be responsible for the concentrated epidemic of cretinism in Central Africa (6266)
These findings suggest that all treatments enhance TGF-1 production, further supporting their anti-inflammatory potential in the brain
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