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Analytical guidance such as ICH Q2(R2) and ICH Q14 supports the broader principle that methods should be fit for purpose and properly documented [13] [14]
Washington DC: The National Academies Press
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Conclusion: Our study findings provide a comprehensive metabolomic knowledge base and other soluble biomarkers for a better understanding of the pathophysiology of LC and suggests sarcosine and serine supplementations might have potential therapeutic implications in LC patients
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