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DSIP crosses the blood-brain barrier freely an unusual property for a peptide of its size via a non-competitive, non-saturable passive mechanism whose physicochemical determinants (lipophilicity, charge, molecular weight, and protein-binding) are now well characterised
doi: 10.1016/bs.afnr.2019.02.005, 81
Serious risks like pancreatitis and thyroid cancer remain largely theoretical based on current human evidence
By comparing one group of study participants who took GLP-1 drugs to a second group of study participants who took aspirin, researchers found that the people taking GLP-1 drugs were less likely to develop colorectal cancer than those taking aspirin over 5-6 years
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