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For patients requiring an injectable medication, GLP-1 RAs are preferred to insulin due to similar or even better efficacy in A1C reduction, lower risk of hypoglycemia, and reductions in body weight

Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12

most evidence remains preclinical

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