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This magnitude of weight reduction in people with T2D [type 2 diabetes] has not been seen with any medications in a phase 3 study before. Comparatively, Wegovy has been found to help people lose an average of 10% of their body weight in a year and Zepbound 15%
Diabetic retinopathy : Rapid improvements in blood glucose control have been associated with worsening of diabetic retinopathy in some patients
In humans, intravenous cocaine injection was shown to decrease plasma GLP-1 concentration, while endogenous GLP-1 was associated with subjective responses to cocaine 90
Large trials show fewer heart attacks and strokes with GLP-1 use through improved endothelial function, reduced oxidative stress, and better nitric oxide availability. If other benefits manifest at lower doses, cardiovascular protection likely does too
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