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Traditionally known for regulating fatty acid oxidation, PPAR also acts as a transcriptional activator of autophagy, especially during fasting
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343 A dietary restriction regimen retarded the progression of neuropathological, behavioral, and metabolic abnormalities in an HD model, resulting in an extension of life span by increasing brain-derived neurotrophic factor and chaperone heat-shock protein-70 (HSP70) levels in the striatum and cortex, the mechanisms of which still need further explanation
Cellular & Molecular Biology Letters
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