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The pathogenesis of predictive and idiosyncratic DILI is intrinsically linked in the pathways that trigger hepatotoxicity, and both have intrinsic immune and inflammatory responses in the body

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The prolonged expression of flavonoid biosynthetic genes reported in several stress-tolerant genotypes (Yadav et al., 2021) is consistent with this hypothesis, although direct mechanistic links between stress memory and flavonoid-specific chromatin regulation remain to be established

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