retatrutide and fatigue most grapplers are only looking at the scale, not what the process is doing to their performance, that’s the dangerous part with Retatrutide, because right now it isn’t even approved yet, meaning After a lot of questions

4.2 Hepatic metabolic modulation effects by GLP-1RAs GLP-1RAs replicate the action of the incretin hormone GLP-1, which primarily involves boosting insulin release, reducing glucagon secretion, and increasing feelings of fullness, ultimately leading to improved glycemic control and supporting weight management (Xu et al., 2024)

Casamenti F, Stefani M

Whatever was going wrong, it was happening further downstream, somewhere in the signaling cascade after the hormone docks with its receptor

Nuclear IGF-IR can not only bind to IGF-IR promoter DNA and promotes the transcription of itself [85], but also directly binds DNA and recruit RNA polymerase II to upregulate JUN and FAM21 expression in cancer cells [86]