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The glutamine transporter SLC7A8 on the membrane of tumor cells plays an important role in the process of drug resistance

Characterization of the GSTU10-10 isoenzyme revealed that it has an antioxidant catalytic function by acting as a hydroperoxidase and has a very low K m for GSH suggesting that GSTU10-10 is able to perform efficient catalysis under conditions where GSH concentrations are low, e.g., during oxidative stress (Skopelitou et al., 2015)

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There are also some cases where specific GSTs are not able to conduct peroxidase activity, such as theta class GSTs [134, 135]