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Holst, T
eker, niasta iermez
Endoscopic therapies, including intragastric balloon therapy and endoscopic sleeve gastroplasty, generally produce more modest weight loss, often approximately 10%-13% at 6 months depending on procedure, patient selection, and follow-up intensity
This is analogous to the evidence pathway followed for liraglutide (LEADER trial, NEJM 2016) and semaglutide (SUSTAIN-6 trial, NEJM 2016), which established cardiovascular benefit for those agents only after large, long-term CVOTs reported [6] The heart rate increase warrants ongoing surveillance, particularly in patients with pre-existing cardiac conditions Phase 3 trials are currently underway (see ClinicalTrials.gov and the EU Clinical Trials Information System, CTIS, for registered studies)
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