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and you have a preexisting history of musculoskeletal diseases, it puts you at greater risk of lower tolerance to exercise

The trial participants were at very high risk for subsequent cardiovascular events with 68% having had a heart attack (82% had coronary artery disease) and the rest with prior stroke or peripheral arterial disease or a combination of these entry criteria

As always, its best to talk to your doctor about whether taking them together is right for you and how to adjust your diet and medication schedule to minimize side effects

Granata A, Maccarrone R, Anzaldi M, Leonardi G, Pesce F, Amico F, et al