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The ADA 2026 Standards of Care now recommend GLP-1 receptor agonists with demonstrated cardiovascular benefit for patients with type 2 diabetes and established ASCVD, multiple cardiovascular risk factors, or chronic kidney disease, and note that combination with SGLT2 inhibitors may provide additive benefit

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While this efficiency is generally beneficial, in environments of excess caloric intake it may contribute to fat accumulation

Response may vary across age groups, though evidence for consistent age-related differences in onset of action is limited