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This amplification of HGF/c-Met signaling promotes the formation of new synaptic connections between neurons, a process critical for learning, memory formation, and cognitive resilience

Supplementary material The Supplementary Material for this article can be found online at: Glossary 16S rDNA 16S ribosomal DNA 16S rRNA 16S ribosomal RNA AGs arabinogalactans AIA adjuvant-induced arthritis ASC apoptosis-associated speck-like protein containing a CARD ASP Angelica sinensis polysaccharide ASPS Acanthopanax senticosus polysaccharide BMD bone mineral density BP Bletilla striata polysaccharides BS bone surface BV bone volume BV/TV bone volume/total volume cDHPS Dendrobium huoshanense stem polysaccharide CFA complete Freunds adjuvant CIA collagen-induced arthritis DBZP Dianbaizhu polysaccharide DOPs Dendrobium officinale polysaccharides ESP Ephedra sinica polysaccharide F/B ratio Firmicutes/Bacteroidota ratio GGC -glutamylcysteine GLP Ganoderma lucidum polysaccharides GSH glutathione HDAC histone deacetylase HWE hot water extraction IL-1 interleukin-1 alpha IL-1 interleukin-1 beta IL-6 interleukin-6 IL-10 interleukin-10 IL-12 interleukin-12 IL-17 interleukin-17 IL-17A interleukin-17A JAK/STAT3 Janus kinase/signal transducer and activator of transcription 3 LBP Lycium barbarum polysaccharide LJCP-2b Lonicerae Japonicae Caulis polysaccharide 2b LPS lipopolysaccharide LPPs litchi pericarp polysaccharides MAE microwave-assisted extraction MDA malondialdehyde MyD88 myeloid differentiation primary response 88 NF-B nuclear factor-kappa B NIP Notopterygium incisum polysaccharide NLRP3 NLR family pyrin domain containing 3 PCP Poria cocos polysaccharides PLE pressurized liquid extraction PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses PROSPERO International Prospective Register of Systematic Reviews PS polysaccharide RA rheumatoid arthritis RA-FLS rheumatoid arthritis fibroblast-like synoviocytes RCT randomized controlled trial ROS reactive oxygen species SAM S-adenosylmethionine SCFAs short-chain fatty acids SDP Saposhnikovia divaricata polysaccharide SMI structure model index SOD superoxide dismutase SYRCLEs RoB tool Systematic Review Centre for Laboratory Animal Experimentations Risk of Bias tool Tb.N trabecular number Tb.Th trabecular thickness TCM traditional Chinese medicine TCMPs traditional Chinese medicine polysaccharides TF-P Thladiantha dubia fruit crude polysaccharide Th17 T helper 17 cell TLR4 Toll-like receptor 4 TNF- tumor necrosis factor-alpha TP Tetrastigma hemsleyanum polysaccharides TRAF6 TNF receptor associated factor 6 Treg regulatory T cell TV total volume UAE ultrasound-assisted extraction WTD Wu-tou decoction

Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice

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