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Key Benefits and Clinical Applications Muscle Growth and Repair IGF-1 LR3 powerfully stimulates muscle protein synthesis and satellite cell activation, supporting significant muscle growth and enhanced recovery from intense training

NICE guidance advises against this combination because both medications work through the incretin system, and the additional glucose-lowering benefit of using them together is modest

They might recommend dropping back to your previous dose level for one injection before returning to your current dose

Mood disturbances reported by patients typically develop within 26 weeks of starting tirzepatide, though onset can vary