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This trial was strengthened by a double-blind, placebo-controlled design with patients from different countries
Measurable weight loss typically begins by weeks 4-8 and continues steadily for 16-20 months
A high-quality multivitamin covers micronutrient gaps from reduced food intake
The authors identified that the dorsal raphe nucleus (DR) has serotonergic neurons that secrete serotonin to hypothalamic nuclei and that GLP-1R activation promotes the activity of DR serotonin neurons
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