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Stopping injections will lead to recurrence of deficiency, as the underlying malabsorption cannot be corrected

"Its worth noting that vitamin B12 stores in the body can last for around 2-4 years without being replenished," it adds

Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption [6] [8] Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency

The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks