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The large cardiovascular outcomes trials of GLP-1 receptor agonists (LEADER, SUSTAIN-6 and REWIND) have confirmed that this class of medication can lower major adverse cardiovascular events by 12-14% in high-risk individuals, and the link between percent weight loss and cardiovascular risk reduction has led to the expectation that higher percent weight loss will yield greater incremental cardiovascular benefits if this class of drug can be used in combination with amylin receptor agonists
At the same time, comfort continues to be a key priority
Orthostatic hypotension is specifically defined as a drop of 20 mmHg in systolic or 10 mmHg in diastolic blood pressure within 3 minutes of standing
FAQs The frequency of B12 injections varies: initially, they may be given weekly or biweekly to address severe deficiency, then reduced to monthly or less often for maintenance
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