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Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: optimization, in vitro release, ocular tolerance, and antibacterial activity

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Through these mechanisms, SIN helps to maintain the dynamic balance between M1 and M2 macrophages, reduces macrophage chemotaxis and secretion, and inhibits macrophage apoptosis, thereby exerting potent immunosuppressive effects (Figure 4)

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