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Those with severe kidney or liver dysfunction should proceed with caution, as impaired organ function may slow peptide clearance
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The positive outcomes of agents like canakinumab and colchicine suggest that effective strategies must precisely target the key nodessuch as the IL-1 pathway or the NLRP3 inflammasomethat directly perpetuate the vicious cycle between oxidative stress and inflammation detailed in Section 2.4.1
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