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Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases
Factors that accelerate expiration Temperature fluctuations: Repeated freeze-thaw cycles very damaging Each thaw = period of degradation One freeze-thaw: Minor impact Multiple cycles: Significant loss of potency Keep frozen continuously until ready to reconstitute Light exposure: UV and visible light degrade peptides Some peptides more photosensitive (GHK-Cu) Amber vials protect partially Keep vials in boxes or dark storage Air exposure: Oxygen causes oxidation Minimize time vial is open Don't store without cap Use quickly after reconstitution Moisture exposure (for powder): Even atmospheric humidity can start degradation Keep in sealed vials always Don't open unnecessarily Store in dry environment Contamination: Non-sterile technique introduces bacteria Bacterial enzymes destroy peptides rapidly Always use alcohol wipes Never touch rubber stopper Use bacteriostatic water to inhibit growth pH extremes: Some peptides unstable at wrong pH Reconstitute with appropriate solution Bacteriostatic water usually optimal (slightly acidic) Don't mix with other substances without knowledge Shelf life before reconstitution (lyophilized powder) How long dry peptides last in different conditions
Theres also some initial data showing increased availability of free testosterone thanks to these drugs, as well as improved sperm quality, though data is mixed
I suppose this is understandable, but I have to tell you as a researcher who works with electronic health record data, if I couldnt drill down to the patient level, Id be very unsure what was actually going on
