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While originally developed to address growth hormone deficiencies in individuals with HIV-associated lipodystrophy syndrome, Tesamorelin has found applications beyond HIV treatment
Cellular readouts in 3T3-L1 adipocytes: decreased 1-MNA, increased NAD and SAM, and reduced lipogenesis after 5-Amino-1MQ exposure [1,6,7]
Direct preparation of very dilute solutions from lyophilized powder is less precise
Endpoints: wound closure rate (planimetry, ImageJ), granulation tissue (histological scoring), collagen organization (Picrosirius red), re-epithelialization (H&E), tensile strength (mechanical testing)
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