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Consistent with this, KEGG pathway analysis revealed downregulation of -oxidation in KO mice, accompanied by upregulation of glycolysis and mitochondrial oxidative phosphorylation, reflecting a systemic shift in fuel preference toward carbohydrates driven by carnitine depletion and impaired fatty acid oxidation

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The mechanism itself is plausible: copper acts as a cofactor for enzymes involved in skin's repair and collagen processes, which is partly why GHK-Cu has drawn so much interest