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Tirzepatide and semaglutide are both incretin-based medications that lower blood sugar and promote weight loss, but they work through different pathwayssemaglutide targets the GLP-1 receptor alone, while tirzepatide activates both GLP-1 and GIP receptors

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Once inactivated, insulin secretions stop, and glucagon, the hormone responsible for increasing blood sugar levels, is also suppressed[3]

As a result, these less-expensive weight loss drug alternatives remain available, though experts remain concerned about their safety and efficacy