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Novo Nordisk has not included vision loss caused by NAION as a side effect of Rybelsus or other drugs using semaglutide

While this is generally not clinically significant, patients on multiple blood pressure medications should be monitored for hypotension, particularly if initiating magnesium supplementation alongside GLP-1 therapy, which may also contribute to modest blood pressure reductions through weight loss

Clinical trials suggest that patients who achieve at least 5% body weight loss by months three to four are likely to be long-term responders