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Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers

Well-characterized mechanism including appetite suppression, glucose-dependent insulin secretion, and gastric emptying delay

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A cooperative role of NRF2 and C/EBP (a transcription factor of the CCAAT/enhancer binding protein family) was described in generating tumor-specific enhancers that promote tumor initiation via NOTCH3 activation (Okazaki et al, 2020)