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Primary Cellular Pathways GHRH Receptor Activation Sustained Pituitary Stimulation CJC-1295 (NO DAC) functions as a modified growth hormone-releasing hormone analog that binds to GHRH receptors on somatotroph cells in the anterior pituitary gland
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They showed that administration of their modified long-acting OXM peptide led to a decrease in food intake and increased weight loss in addition to improved metabolic profile, superior to GLP-1 alone over 14 days in diet-induced obese (DIO) mice (69)
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