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Perspective on the Rx Pipeline: Diabetes and GLP-1 Agonists Situation Summary Initial therapy for individuals with T2DM who are at high risk for CVD, heart failure (HF) and/or chronic kidney disease is metformin and a glucagon-like peptide 1 (GLP-1) or sodium glucose transporter ligand 2 (SGLT-2)

The Primary liver cells were isolated from male rat liver by two-step collagenase perfusion method according to Seglen [15] and were cultured in collagen-coated 96-well plates and 25 cm 2 tissue culture flasks in DMEM without phenol red

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