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At 16 weeks: 100% response rate in multiple endpoints at the 45 mg dose Rapid separation from placebo as early as Week 4 Clear dose-dependent efficacy signal 2 Clinically meaningful, not just statistically significant Key efficacy highlights: CSAMI-A score: 45 mg: 22.3 points Placebo: 0.7 points 100% of patients on 45 mg achieved a 10-point clinically meaningful improvement 69% achieved near-clear or clear skin on Investigators Global Assessment 3 External validation from clinical leaders Misha Rosenbach, M.D

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Eleven percent of the US population has taken GLP-1 drugs for diabetes or weight reduction, and, as a result, have been spending less on food and consuming fewer calories