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The table below highlights how often some of these symptoms were reported in clinical trials, along with strategies that may help make them easier to manage
The main downside was the nausea, which was consistent while taking both drugs
What the Clinical Data Actually Shows The most definitive comparison comes from the SURMOUNT-5 trial, a direct head-to-head study published in the New England Journal of Medicine comparing tirzepatide 10 mg and 15 mg against semaglutide 2.4 mg in adults with obesity but without diabetes
Where to inject semaglutide Semaglutide injection sites include three areas: the abdomen (stomach), the front of the thigh, and the upper arm
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