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Hypercortisolism also causes insulin resistance (which can lead to the development of type 2 diabetes mellitus), excessive bone resorption (which can lead to osteoporosis), and hypertension
The enzyme glutamine synthetase (GS) utilizes ATP and ammonia to transform glutamate into glutamine
All data are expressed as the mean SD from at least three biological replicates, and comparisons between the two groups were performed with a nonparametric method (MannWhitney U test)
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