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Practical tips for staying hydrated on weight loss medication: Keep a water bottle nearby and aim to sip consistently rather than drinking large amounts infrequently Monitor urine colour pale straw yellow is a good indicator of adequate hydration Avoid excessive alcohol, which can worsen dehydration If experiencing vomiting or diarrhoea, consider oral rehydration solutions to replace lost electrolytes If you are unable to maintain adequate fluid intake due to persistent vomiting or diarrhoea, contact your prescriber or seek medical advice promptly Kidney health deserves particular consideration

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In the present study, the decrease in folate and increase in glycine concentrations in the CrO+D group demonstrate the modulation of the flux through remethylation induced by creatine supplementation