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Experts say, The goal of initial therapy is to correct the deficiency and replenish body stores. The goal of initial therapy is to correct the deficiency and replenish body stores. Clinical Guidelines on Vitamin B12 Deficiency Proper Injection Techniques and Sites Administering Vitamin B12 injections intramuscularly needs proper technique for safety and effectiveness

large doses might diminish the effectiveness of antidiabetic medications (like insulin, metformin, or sulfonylureas)

Raun et al., Ipamorelin, the first selective growth hormone secretagogue, Endocrinology, November 1998

This is especially important during pregnancy and breastfeeding when more vitamin B12 is needed