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Peptide drugs had a reputation for being hard to develop, expensive to make, and inconvenient for patients, who usually had to inject them
Methods Study population The study population included individuals from four U.S.-based prospective cohort studies: the Cancer Prevention Study-II (CPS-II) [20], the Cancer Prevention Study-3 (CPS-3) [21], the Multiethnic Cohort (MEC) [22], and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Cohort (PLCO) [23]
There is significant evidence that, besides inducing overexpression of the genetic expression and an increase in apoptosis inhibitory proteins (Bcl-2, Bcl-xL, XiAP), IL-8 can also inhibit proteolytic activation of caspase-3
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