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Oral semaglutide tablets are designed for sublingual absorption, allowing systemic effects without injection
Cagrilintide is a newer long-acting amylin analogue - in a phase 2 trial, once weekly cagrilintide resulted in a dose-dependent WL between 6 and 10.8% compared to 9% with liraglutide 3 mg and 3% with placebo [87]
Few commercial payers cover GLP-1s for weight loss alone (e.g., some Blue Cross Blue Shield plans cover Wegovy), and only for certain plans/tiers and if stringent criteria are met (e.g., body mass index (BMI) above a certain threshold)
Protocols vary by route no single standardised regimen
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