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Semaglutide works through several mechanisms: Appetite regulation : It acts on receptors in the brain's appetite centres, particularly the hypothalamus, reducing hunger and increasing feelings of fullness Gastric emptying : It slows the rate at which food leaves the stomach, prolonging satiety Glucose regulation : It enhances insulin secretion when blood glucose is elevated and suppresses inappropriate glucagon release The medication reaches steady-state concentrations after approximately 45 weeks of regular dosing, with a half-life of about one week
Thondam SK, Cuthbertson DJ, Wilding JPH (2020) The influence of glucose-dependent insulinotropic polypeptide (GIP) on human adipose tissue and fat metabolism: implications for obesity, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD)
