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Participants showed significant reductions in waist circumference, systolic and diastolic blood pressure, glycated hemoglobin, fasting glucose, insulin levels, and lipid profiles
For someone with an HbA1c stubbornly stuck above 8-9% despite metformin, that gap can be clinically meaningful
Semaglutide works through multiple mechanisms: it enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying
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