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Both medications are injected subcutaneously (under the skin) of the thigh, abdomen, or upper arm once a week
How long tirzepatide takes to work is typically 1-2 weeks for appetite effects and 4-8 weeks for measurable weight loss
Bariatric surgery remains an option for patients with severe obesity who meet specific NICE criteria generally a BMI of 40 or above, or 35 or above with significant comorbidities, with lower thresholds applicable in some groups, such as those with recent-onset type 2 diabetes
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