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This intense inflammation is associated with damaging systemic events like oxidative stress, dysregulation of iron homeostasis, hypercoagulability and thrombus formation, acute respiratory distress syndrome, uncontrolled inflammation and organ failure (251257) (Figure 8)

suggests that treatment with NB-UVB phototherapy in combination with PL increases the extent of repigmentation and thus shortens the repigmentation time in patients with diffuse vitiligo at lower cumulative doses [138]