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The primary end points were risk of cardiometabolic, psychiatric, and autoimmune sequelae of psoriasis, all-cause mortality, and potential adverse drug events
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In the Phase 3 TRIUMPH-4 trial (68 weeks), retatrutide demonstrated unprecedented weight loss in adults with obesity and knee osteoarthritis, with participants on the highest dose (12 mg) achieving an average weight loss of 28.7% (approximately 71 lbs)
This makes sense given their mechanism
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