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IGF-1 elevations followed, increasing 1.5 to 3-fold for 9 to 11 days after a single dose
The same safety recommendations with name-brand GLP-1s apply to compounded versions
Across the class, dosing rhythm weekly or daily depending on the compound is what sustains receptor engagement over time, and it shapes how a regimen fits into a life as much as the molecule itself does
Furthermore, an alteration in cell state and expression profile (i.e., increase in pro-inflammatory cytokines and nitric oxide) was observed in cultured BV-2 cells treated with a CB 1 R antagonist (Lou et al., 2018)
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