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These checkpoints consist of inhibitory or activating pathways and molecules predominantly expressed by MDSCs, which govern their immunosuppressive behavior

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Glutathione reductase (GR), an NADPH-dependent enzyme, continuously regenerates reduced glutathione (GSH) from its oxidized form (GSSG), thereby maintaining the intracellular reducing environment required for effective antioxidant defense, proper enzymatic activity, and redox-dependent signaling pathways [36]

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