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An intracellularly expressed single-chain variable fragment targeting mitochondrial CD147 (mito-CD147 scFv) effectively disrupts the mitochondrial CD147/MCT1/LDHB complex, inhibits lactate-induced stemness potential, depletes circulating breast cancer cells, and reduces metastatic burden, suggesting promising clinical applications in reducing lactate-fueled metastasis
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Inhibition of matrix metalloproteinase activity disrupts reconsolidation but not consolidation of a fear memory
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Managing Expectations Responsibly Individual results may vary
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