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In patients, HBV circulates in blood as virion DNA and exists in hepatocytes both in nuclear DNA forms (episomal cccDNA, deproteinized double-stranded DNA including relaxed circular DNA and linear DNA and integrated linear DNA) and in cytoplasmic core DNA forms 21
The most reliable approach involves the pharmacy conducting its own stability testing using validated analytical methods
Effects of intensive blood-pressure control in type 2 diabetes mellitus
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