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The Phase 2 and Phase 3 trials so far have shown a safety profile broadly consistent with other GLP-1 medications: gastrointestinal side effects are common, and a new signal called dysaesthesia (an abnormal skin sensation) appears more often at higher doses
Were targeting a separate satiety circuit the brainstem area postrema pathway that GLP-1 agonists alone dont fully engage
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A study on patients with HCM revealed abnormal copper accumulation, and the use of the Cu2+ selective chelator tretinoin hydrochloride was found to slow or reverse disease progression in HCM (73)
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