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GS-conjugates are actively transported out of cells by efflux transporters including MRP1 and P-glycoprotein belonging to the superfamily of ATP-binding cassette transporters 70,71,72

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In addition to BRCA genes, mutations in other high-penetrance genes such as TP53 (associated with Li-Fraumeni syndrome) and PTEN (linked to Cowden syndrome) have been found to be associated with familial breast cancer, as these genes are heritable, keeping women at potential risk to develop cancer during their lifetime ( PALB2, ATM , and CHEK2 (63)

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