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It has been associated with autoimmune diseases such as multiple sclerosis, autoimmune thyroiditis, systemic lupus erythematous, oral lichen planus, rheumatoid arthritis, autoimmune hepatitis and Sjgrens syndrome ( Journal of Oral and Maxillofacial Pathology , Sep-Dec., 2015)

For example, progesterone inhibited NF-B signaling and reduced NO and IL-12 production in LPS-stimulated murine bone marrow-derived and alveolar macrophages, respectively (129132)