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assessing efficacy in all randomized patients regardless of treatment discontinuation) and the efficacy estimand (assessing the treatment effect for randomized participants provided that the treatment was administered as intended)

Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014

Thus, as for WT albumin, the C-terminal end of QMP is susceptible to enzymatic cleavage by CPA

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