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price negotiations and new discount programs should have only a low single digit negative impact on its global sales growth in 2026

Contact your GP or diabetes care team if : Hot flushes are severe, persistent, or significantly impacting quality of life , affecting sleep, work, or daily activities Symptoms are accompanied by chest pain, palpitations, or shortness of breath , which could indicate cardiovascular issues You experience unexplained weight loss beyond what is expected with Ozempic, or other constitutional symptoms such as night sweats Hot flushes occur alongside tremor, anxiety, or heat intolerance , which may suggest thyroid dysfunction (hyperthyroidism) There are changes in menstrual patterns or other hormonal symptoms in premenopausal women You develop new or worsening symptoms after starting Ozempic or increasing the dose Call 999 or seek urgent medical attention if hot flushes are accompanied by: Severe chest pain, difficulty breathing, or symptoms of anaphylaxis Signs of hypoglycaemia (confusion, excessive sweating, trembling, rapid heartbeat) that do not resolve with glucose intake Symptoms of pancreatitis (severe, persistent abdominal pain radiating to the back, nausea, vomiting) Severe dehydration from concurrent vomiting or diarrhoea For urgent concerns that are not life-threatening, contact NHS 111 for advice

Key Findings Tirzepatide 5 mg, 10 mg, and 15 mg doses substantially decreased UACR compared with all combined comparators

Note: Binding capacity is flow rate-and protein-dependent