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The Neh6 domain, which is a serine-rich region, contributes to regulate NRF2 stability and mediates the interaction with a third negative regulator, -transducin repeat-containing protein (-TrCP), through its DSGIS (Aspartic acid-Serine-Glycine-Isoleucine-Serine) and DSAPGS (Aspartic acid-Serine-Alanine-Proline-Glycine-Serine) motifs not recognized by KEAP1

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doi: 10.3390/biom11081226 8 MazurekMLitakJKamieniakPKuleszaBJonakKBajJet al

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Same molecule = same mechanism

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However, they need to make sure the supplement provides acceptable amounts of vitamin B12 made from high-quality ingredients

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