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Moreover, treatment with mitochondria-targeted antioxidant MitoQ preserves mitochondrial quality control, alleviates tubular injury, and restores kidney function by reversing mitophagy deficiency through the Nrf2/PTEN-induced kinase 1 (PINK) signaling pathway in db/db mice (68)
The primary evidence comes from the 2017 Cell paper using aged and chemotherapy-treated mice, and subsequent mechanistic studies
b , After compression injury, SR101-labelled astrocytes (red) at the glial limitans are surrounded by a network of honeycomb microglia (top, xy projection)
These studies span dose ranges that encompass probable human exposures
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